Nuclear cell biology

Nuclear cell biology

How does the nucleus move within the cell? How is the nucleus compartmentalized? How is nuclear size maintained? How is chromatin organized within the nucleus? These are a few of the questions related to nuclear cell biology addressed by our Minisymposium. Dan Starr led off with a description of how nuclei migrate in Caenorhabditis elegans. A KASH protein in the outer nuclear membrane recruits ...

I-12: Nuclear Reprogramming in Bovin Somatic Cell Nuclear Transfer

Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...

Cell biology. In sex reversal, protein deterred by nuclear barrier.

Nuclear Architecture: The Cell Biology of a Laminopathy

Lamin mutations cause muscular dystrophies, but the mechanism is unclear. A new study shows that lamin mutant worms display muscle-specific defects linked to altered subnuclear localization of heterochromatin, leading to altered gene expression.

Cell biology of transcription and pre-mRNA splicing: nuclear architecture meets nuclear function.

Gene expression is a fundamental cellular process. The basic mechanisms involved in expression of genes have been characterized at the molecular level. A major challenge is now to uncover how transcription, RNA processing and RNA export are organized within the cell nucleus, how these processes are coordinated with each other and how nuclear architecture influences gene expression and regulatio...